منابع مشابه
Taking the plunge: recreational water quality guidelines.
During the 1980s, the profile of recreational water quality at Sydney’s beaches caused concern among Sydneysiders. Monitoring of recreational water quality indicated that most Sydney beaches had poor water quality, and this condition was attributed to the disposal of partiallytreated sewage at cliff-face discharges. An epidemiological study conducted in 1989–1990 attempted to determine the prev...
متن کاملZebrafish small molecule screens: Taking the phenotypic plunge
Target based chemical screens are a mainstay of modern drug discovery, but the effectiveness of this reductionist approach is being questioned in light of declines in pharmaceutical R & D efficiency. In recent years, phenotypic screens have gained increasing acceptance as a complementary/alternative approach to early drug discovery. We discuss the various model organisms used in phenotypic scre...
متن کاملTaking the Plunge: Next Steps in Engaged Learning
College and university science educators from across Connecticut gathered at Yale's West Campus in April 2010 for a Project Kaleidoscope (PKAL) program entitled "Taking the Plunge: Next Steps in Engaged Learning." Funded by the National Science Foundation (NSF) and co-sponsored by the Connecticut Conference of Independent Colleges (CCIC) and Yale's McDougal Graduate Teaching Center, the event w...
متن کاملTaking the plunge: California Grunion embryos emerge rapidly with environmentally cued hatching.
The process of hatching has been well studied in some model species of teleosts: the medaka Oryzias latipes, the mummichog Fundulus heteroclitus, and the zebrafish Danio rerio. These models are compared to the California Grunion, Leuresthes tenuis that has some unique features of reproduction related to tidal synchrony of spawning and environmentally cued hatching (ECH). During oviposition at s...
متن کاملTaking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis.
Rhomboid proteases are a fascinating class of enzymes that combine a serine protease active site within the core of an integral membrane protein. Despite having key roles in animal cell signalling and microbial pathogenesis, the membrane-immersed nature of these enzymes had long imposed obstacles to elucidating their biochemical mechanisms. But recent multidisciplinary approaches, including eig...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2011
ISSN: 1554-8627,1554-8635
DOI: 10.4161/auto.7.1.14130